Breast cancer is a malignant (cancer) tumor that starts in the cells of the breast, can invade surrounding tissues or metastasize to distant areas of the body.1
Breast cancer is the most common cancer among women in India and worldwide Over 1,00,000 new breast cancer cases are estimated to occur every year and over 50,000 women are estimated to die of it annually in India.2,3
Breast tumors can be benign or malignant. Benign breast lumps are cysts, fibroadenomas and intraductal papillomas.1
Tumor is less than 2 cm with or without micrometastases in lymph node
Tumor is less than 2 cm in size with 3 axillary lymph node involvement or tumor is of 5 cm in size
Tumor is larger than 2cm but not more than 5cm in size and involve 1-3 axillary lymphnodes
Tumor that involves either 4-9 axillary lymph nodes or > 5 cm in size and involves up to 9 axillary lymph nodes
Women who are at high risk for breast cancer based on certain factors should get an MRI and a mammogram every year. This includes women who:
Radiation therapy is treatment with high-energy rays (such as x-rays) or particles to kill cancer cells. Radiation therapy may be used to kill cancer cells remaining in the breast, chest wall, or underarm area after surgery or, less often, to shrink a tumor before surgery. Radiation to the breast is often needed after breast-conserving surgery. Radiation may also be recommended after mastectomy in patients either with a cancer larger than 5 cm, or when cancer is found in the lymph nodes.It is usually given after any chemotherapy. Radiation is also used to treat cancer that has spread to other areas, for example to the bones or brain.
Chemotherapy (chemo) is the use of cancer-killing drugs. These drugs can be put into a vein, given as a shot, or taken as a pill or liquid. They enter the bloodstream and reach most parts of the body, making this treatment useful for cancers that have spread to distant organs. While these drugs kill cancer cells, they also damage some normal cells, which can lead to side effects.
Chemo can be used either before or after surgery for early-stage breast cancer. This is to kill any cancer cells that may have spread but are too small to be seen by exam or tests.
Chemo can also be used as the main treatment for women with cancer that has spread to distant sites (outside the breast and the nearby lymph nodes).
Most of the targeted drugs used to treat breast cancer target HER2/neu. In some patients, their breast cancer cells have too much of this protein. Certain drugs target this protein, stopping it from causing breast cancer cell growth. These are trastuzumab, pertuzumab, ado Trastuzumab emtansine and lapatinib.
Accurate HER2 testing is extremely important. HER2 testing is done by immunohistochemistry (IHC) assay and by in situ hybridization (ISH) assay on a breast cancer specimen.11
If you are HER2-positive, you can potentially benefit from a therapy that targets HER2.
VivitraTM (Trastuzumab) is a highly biosimilar medicinal product of reference biologic. It is a humanized monoclonal anti-HER2 (Human epidermal growth factor receptor 2) antibody.12
Metastatic Breast Cancer (MBC): VivitraTM (Trastuzumab) is indicated for the treatment of patients with HER2 overexpressing metastatic breast cancer. VivitraTM (Trastuzumab) is also indicated in combination with aromatase inhibitor for the treatment of patients with HER2 overexpressing and hormone receptor-positive metastatic breast cancer.12
Early Breast Cancer (EBC): VivitraTM (Trastuzumab) is indicated for the treatment of patients with HER2 overexpressing early breast cancer following surgery, chemotherapy (neo adjuvant or adjuvant) and radiotherapy (if applicable). VivitraTM (Trastuzumab) is also indicated for adjuvant treatment of patients with HER2 overexpressing node positive or node negative breast cancer i) as part of treatment regimen comprising doxorubicin, cyclophosphamide, and either paclitaxel or docetaxel ii) with docetaxel and carboplatin.12